Diffuse Lewy body disease
Identifieur interne : 002927 ( Main/Exploration ); précédent : 002926; suivant : 002928Diffuse Lewy body disease
Auteurs : W. Dickson [États-Unis] ; P. Davies [États-Unis] ; R. Mayeux [États-Unis] ; H. Crystal [États-Unis] ; S. Horoupian [États-Unis] ; A. Thompson [États-Unis] ; E. Goldman [États-Unis]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1987-01-01.
Abstract
Summary: Post-mortem pathological and biochemical studies are reported on six patients with progressive dementia. The characteristic pathological finding was neurofilament-containing cytoplasmic inclusions in cortical and subcortical neurons. The clinical and pathological findings were consistent with so-called diffuse Lewy body disease. The patients had variable changes of the Alzheimer type, with five of six patients displaying “plaques only” Alzheimer's changes. Biochemical studies showed profound decreases in neocortical choline acetyltransferase (ChAT) activities that correlated with marked neuronal loss in the basal nucleus of Meynert. ChAT activities were normal in the hippocampus in three patients who also had no significant Alzheimer type hippocampal changes. All patients had decreased cortical somatostatin-like immunoreactivity. Our observations suggest that dementia in diffuse Lewy body disease bears biochemical similarities to Alzheimer's disease, in that biochemical markers for both intrinsic cortical neurons and ascending cholinergic neurons are affected.
Url:
DOI: 10.1007/BF00686786
Affiliations:
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Horoupian</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Thompson, A" sort="Thompson, A" uniqKey="Thompson A" first="A." last="Thompson">A. Thompson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology (Neuropathology) and Rose F. Kennedy Center for Research in Mental Retardation and Human Development, 1300 Morris Park Avenue, 10461, Bronx, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Goldman, E" sort="Goldman, E" uniqKey="Goldman E" first="E." last="Goldman">E. 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The characteristic pathological finding was neurofilament-containing cytoplasmic inclusions in cortical and subcortical neurons. The clinical and pathological findings were consistent with so-called diffuse Lewy body disease. The patients had variable changes of the Alzheimer type, with five of six patients displaying “plaques only” Alzheimer's changes. Biochemical studies showed profound decreases in neocortical choline acetyltransferase (ChAT) activities that correlated with marked neuronal loss in the basal nucleus of Meynert. ChAT activities were normal in the hippocampus in three patients who also had no significant Alzheimer type hippocampal changes. All patients had decreased cortical somatostatin-like immunoreactivity. Our observations suggest that dementia in diffuse Lewy body disease bears biochemical similarities to Alzheimer's disease, in that biochemical markers for both intrinsic cortical neurons and ascending cholinergic neurons are affected.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li><li>État de New York</li></region><settlement><li>New York</li></settlement><orgName><li>Université Columbia</li></orgName></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Dickson, W" sort="Dickson, W" uniqKey="Dickson W" first="W." last="Dickson">W. Dickson</name></region><name sortKey="Crystal, H" sort="Crystal, H" uniqKey="Crystal H" first="H." last="Crystal">H. Crystal</name><name sortKey="Davies, P" sort="Davies, P" uniqKey="Davies P" first="P." last="Davies">P. Davies</name><name sortKey="Goldman, E" sort="Goldman, E" uniqKey="Goldman E" first="E." last="Goldman">E. Goldman</name><name sortKey="Horoupian, S" sort="Horoupian, S" uniqKey="Horoupian S" first="S." last="Horoupian">S. Horoupian</name><name sortKey="Mayeux, R" sort="Mayeux, R" uniqKey="Mayeux R" first="R." last="Mayeux">R. Mayeux</name><name sortKey="Thompson, A" sort="Thompson, A" uniqKey="Thompson A" first="A." last="Thompson">A. Thompson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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